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Autoantibodies against NMDAR, AMPAR, GABAR, LGI1, CASPR2

Autoimmune Encephalitis Mosaic 1

Transfected cells: antibodies against NMDAR and CASPR2 (top), AMPAR1 and LGI1 (middle), AMPAR2 und GABAB-R (bottom)

  • Screening test for detection of neuropil antibodies (glutamate receptors type NMDA and type AMPA, LGI1, CASPR2, GABABreceptors).
  • Indication: autoimmune encephalitis.
  • Immunohistochemistry with tissue sections of rat hippocampus and rat cerebellum allows identification of antibodies against glutamate receptors (type NMDA, type AMPA) and other antibodies (e.g. VGKC-associated proteins LGI1 and CASPR2). The parallel use of transfected HEK293 cells enables sensitive and monospecific antibody detection and differentiation of various neuropil antibodies.
  • Neuropil antibodies show a flat, smooth to fine-granular fluorescence in the cytoplasm of transfected HEK293 cells. Clinical significance: autoimmune encephalitis.

Technical info and Images credit to EUROIMMUN AG