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Thyroid-specific autoantibodies

Thyroid gland and thyroglobulin antigen

Thyroid gland, unfixed and thyroglobulin BIOCHIP: antibodies against thyroid microsomes and thyroglobulin

  • Detection of antibodies against thyroid gland antigens.
  • Indications: Graves' disease, Hashimoto's autoimmune thyroiditis.
  • Using unfixed thyroid tissue, two important thyroid-specific antibodies can be found: Autoantibodies against thyroid microsomes (MAb) give a granular staining in the cytoplasm of the follicle epithelium (target antigen: thyroid peroxidase, TPO). Autoantibodies against thyroglobulin (TAb) react with the colloid of all follicles of the thyroid tissue and cause a reticular fluorescence pattern.
  • With the thyroglobulin-coated BIOCHIP, autoantibodies against thyroglobulin (TG) can be confirmed monospecifically in one and the same test procedure.

Anti-thyroglobulin, anti-thyroid peroxidase, anti-TSH receptor

Anti-thyroid antigen ELISAs

  • Monospecific determination of antibodies against thyroglobulin (TG), thyroid peroxidase (TPO), and thyrotropin receptor (TSH-R).
  • Indications: Graves' disease, Hashimoto's autoimmune thyroiditis.
  • The quantification is carried out according to international reference preparations (anti-TG: NIBSC 65/93; anti-TPO: NIBSC 66/387; anti-TSH-R: NIBSC 90/672).
  • Thyroglobulin/TSH-R: native antigen; thyroid peroxidase: recombinant antigen.

Technical info and Images credit to EUROIMMUN AG