Thyroid-specific autoantibodies
Thyroid gland and thyroglobulin antigen
Thyroid gland, unfixed and thyroglobulin BIOCHIP: antibodies against thyroid microsomes and thyroglobulin
- Detection of antibodies against thyroid gland antigens.
- Indications: Graves' disease, Hashimoto's autoimmune thyroiditis.
- Using unfixed thyroid tissue, two important thyroid-specific antibodies can be found: Autoantibodies against thyroid microsomes (MAb) give a granular staining in the cytoplasm of the follicle epithelium (target antigen: thyroid peroxidase, TPO). Autoantibodies against thyroglobulin (TAb) react with the colloid of all follicles of the thyroid tissue and cause a reticular fluorescence pattern.
- With the thyroglobulin-coated BIOCHIP, autoantibodies against thyroglobulin (TG) can be confirmed monospecifically in one and the same test procedure.
Anti-thyroglobulin, anti-thyroid peroxidase, anti-TSH receptor
Anti-thyroid antigen ELISAs
- Monospecific determination of antibodies against thyroglobulin (TG), thyroid peroxidase (TPO), and thyrotropin receptor (TSH-R).
- Indications: Graves' disease, Hashimoto's autoimmune thyroiditis.
- The quantification is carried out according to international reference preparations (anti-TG: NIBSC 65/93; anti-TPO: NIBSC 66/387; anti-TSH-R: NIBSC 90/672).
- Thyroglobulin/TSH-R: native antigen; thyroid peroxidase: recombinant antigen.
Technical info and Images credit to EUROIMMUN AG