Untitled Document
AUTOANTIBODIES AGAINST TISSUE TRANSGLUTAMINASE (tTG)

Anti-tissue transglutaminase

Anti-Tissue Transglutaminase ELISA

  • Monospecific detection of antibodies against tissue transglutaminase.
  • Indications: gluten-sensitive enteropathy (coeliac disease, non-tropical sprue), Duhring's herpetiform dermatitis.

Coeliac Disease Profile

The serological detection of disease-specific antibodies (IgA and IgG) is an essential element of coeliac disease diagnostics. Especially IgA antibodies against tTG are considered the most specific and sensitive indicator. A 10-fold increased antibody concentration of the upper threshold value of the normal range (10x upper limit of normal, > 10 x ULN) is considered as a threshold value for the diagnosis of coeliac disease without an additional biopsy. In addition, the gliadin-GAF-3X antigen was developed for the detection of IgA and IgG antibodies directed against relevant, deamidated gliadin epitopes.

  • Parallel qualitative in vitro determination of human antibodies against tissue transglutaminase (tTG) and gliadin-analogue fusion peptide (GAF-3X)
  • Identification of a possible IgA deficiency using serum/plasma control bands

Technical info and Images credit to EUROIMMUN AG