Anti-Tissue Transglutaminase ELISA
The serological detection of disease-specific antibodies (IgA and IgG) is an essential element of coeliac disease diagnostics. Especially IgA antibodies against tTG are considered the most specific and sensitive indicator. A 10-fold increased antibody concentration of the upper threshold value of the normal range (10x upper limit of normal, > 10 x ULN) is considered as a threshold value for the diagnosis of coeliac disease without an additional biopsy. In addition, the gliadin-GAF-3X antigen was developed for the detection of IgA and IgG antibodies directed against relevant, deamidated gliadin epitopes.
Technical info and Images credit to EUROIMMUN AG