Autoantibodies against NMDAR, AMPAR, GABAR, LGI1, CASPR2
Autoimmune Encephalitis Mosaic 1
Transfected cells: antibodies against NMDAR and CASPR2 (top), AMPAR1 and LGI1 (middle), AMPAR2 und GABAB-R (bottom)
- Screening test for detection of neuropil antibodies (glutamate receptors type NMDA and type AMPA, LGI1, CASPR2, GABABreceptors).
- Indication: autoimmune encephalitis.
- Immunohistochemistry with tissue sections of rat hippocampus and rat cerebellum allows identification of antibodies against glutamate receptors (type NMDA, type AMPA) and other antibodies (e.g. VGKC-associated proteins LGI1 and CASPR2). The parallel use of transfected HEK293 cells enables sensitive and monospecific antibody detection and differentiation of various neuropil antibodies.
- Neuropil antibodies show a flat, smooth to fine-granular fluorescence in the cytoplasm of transfected HEK293 cells. Clinical significance: autoimmune encephalitis.
Technical info and Images credit to EUROIMMUN AG