AUTOANTIBODIES AGAINST ISLET CELLS (ICA), GAD, IA2, ZnT8, insulin
Pancreas
Primate pancreas: Antibodies against islet cells
- Detection of antibodies against islet cells of the pancreas (ICA).
- Indication: Type I diabetes mellitus, differentiation between late manifestation of type 1 diabetes mellitus (latent autoimmune diabetes in adulthood, LADA) from type 2 diabetes.
- With indirect immunofluorescence autoantibodies against pancreas islets (ICA) can be detected in 80% of patients with new-onset diabetes type 1. Characteristic target antigens of ICA are the enzyme glutamic acid decarboxylase (GAD) and tyrosine phosphatase (IA2).
Anti-GAD, anti-IA2, anti-ZnT8, anti-GAD/IA2 Pool
Anti-GAD ELISA
- Monospecific detection of antibodies against glutamic acid decarboxylase (GAD), tyrosine phosphatase (IA2), zinc transporter 8 (ZnT8) or bispecific detection of anti-GAD and anti-IA2 in a single reagent.
- Indications: early diagnosis of type 1 diabetes mellitus, risk prediction in first grade relatives, prognosis of the clinical progression of type 1 diabetes for prediction of insulin dependence, differential diagnosis in gestational diabetes, differentiation between a late manifestation of type 1 diabetes (latent autoimmune diabetes in adulthood, LADA) and type 2 diabetes.
Anti-Insulin
Anti-Insulin RIA
- Monospecific detection of antibodies against insulin.
- Indications: Early diagnosis of diabetes mellitus type 1, risk prediction in first grade relatives, prognosis of the clinical progression of type 1 diabetes for prediction of insulin dependence.
Technical info and Images credit to EUROIMMUN AG