Untitled Document
AUTOANTIBODIES AGAINST ISLET CELLS (ICA), GAD, IA2, ZnT8, insulin

Pancreas

Primate pancreas: Antibodies against islet cells

  • Detection of antibodies against islet cells of the pancreas (ICA).
  • Indication: Type I diabetes mellitus, differentiation between late manifestation of type 1 diabetes mellitus (latent autoimmune diabetes in adulthood, LADA) from type 2 diabetes.
  • With indirect immunofluorescence autoantibodies against pancreas islets (ICA) can be detected in 80% of patients with new-onset diabetes type 1. Characteristic target antigens of ICA are the enzyme glutamic acid decarboxylase (GAD) and tyrosine phosphatase (IA2).

Anti-GAD, anti-IA2, anti-ZnT8, anti-GAD/IA2 Pool

Anti-GAD ELISA

  • Monospecific detection of antibodies against glutamic acid decarboxylase (GAD), tyrosine phosphatase (IA2), zinc transporter 8 (ZnT8) or bispecific detection of anti-GAD and anti-IA2 in a single reagent.
  • Indications: early diagnosis of type 1 diabetes mellitus, risk prediction in first grade relatives, prognosis of the clinical progression of type 1 diabetes for prediction of insulin dependence, differential diagnosis in gestational diabetes, differentiation between a late manifestation of type 1 diabetes (latent autoimmune diabetes in adulthood, LADA) and type 2 diabetes.

Anti-Insulin

Anti-Insulin RIA

  • Monospecific detection of antibodies against insulin.
  • Indications: Early diagnosis of diabetes mellitus type 1, risk prediction in first grade relatives, prognosis of the clinical progression of type 1 diabetes for prediction of insulin dependence.

Technical info and Images credit to EUROIMMUN AG