The membrane-bound HLA-B27 protein is associated with the occurrence of several autoimmune diseases, such as ankylosing spondylitis (Bechterew's disease). Around 3 to 6 % of HLA-B*27 carriers develop ankylosing spondylitis. Around 90% of ankylosing spondylitis patients are carriers of this tissue antigen. HLA-B27 Direct detects all currently known HLA-B*27 subtypes. Furthermore, when a positive result is obtained, it is indicated whether the subtypes HLA-B*27:06 or HLA-B*27:09 could be present. These two subtypes are not associated with ankylosing spondylitis.
Technical info and Images credit to EUROIMMUN AG